Voacanga Africana Enter Into The World of Botanic Dreams

Voancanga Africana Root Bark the new sources of Ibogaine.

V. africana rootbark to ibogaine HCl

been looking into this potential and economically viable conversion of voacangine to ibogaine.

V.africana rootbark goes for about 140E/kg, containing up to 10% voacangine.

simple acetic acid or methanol extraction yield the total alkaloid.

voacangine is easily converted to ibogaine.

the tricky part is separating the voacangine from the rest of the similar alks in the mixture.

"Voacangine has a molecule which is the same as ibogaine except there is a
group, -CO2CH3, hanging off, where ibogaine has only a -H atom. If this
group is removed, then voacangine becomes ibogaine. Boiling voacangine in
alcohol which contains lye causes the CH3 to fall off and be replaced by an
Na, so now there is a -CO2Na dangling from the ibogaine molecule. If acid
is added, the Na is replaced by H to give a -CO2H group. When warmed
gently, this group releases carbon dioxide, CO2, so that only the -H is
left, and ibogaine is obtained.
The patent also says that, given this easy conversion of voacangine into
ibogaine, it is better to make ibogaine from voacangine than to extract it
directly from Tabernanthe iboga. The reasons for this are that the Voacanga
africana tree whose bark contains lots of voacangine is much more
widespread than T. iboga, and the bark can be harvested more easily than
root can, and the bark can be harvested in a manner which allows the tree
to live."

The most promising alternative source of ibogaine was its semisynthesis from voacangine, obtained from the bark of the Voacanga africana tree. A patent (10) by Janot and Goutarel claims that while T. iboga root bark contains only 0.3% ibogaine, the more abundant and accessible trunk bark of V. africana contains 0.5% voacangine, which can be easily converted into ibogaine. Extraction of V. africana trunk bark using vinegar (see the experimental section) was highly successful in isolating crude alkaloids. However, extensive attempts to isolate or even identify voacangine in this mixture, or to convert the mixture into ibogaine according to the patent, were completely unsuccessful. A later publication (13) found only 0.14% voacangine in the bark, and suggests that the concentration of voacangine varies.

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